Tag: pharmacological
Statistical modelling promises better identification of drug-induced AKI
Drug-induced acute kidney injury (DI-AKI) is “challenging to distinguish” from other types of AKI even for “experienced nephrologists”, yet this adverse drug event (ADE)...
Positive budesonide trial results earn FDA drug application approval
Calliditas Therapeutics has announced that the US Food and Drug Administration (FDA) has accepted a submission for a supplemental New Drug Application (sNDA) for...
Phase 1 study of kidney transplant rejection drug initiated
Tonix Pharmaceuticals has announced the initiation of a Phase 1 single ascending dose escalation study of TNX-1500 (Fc-modified humanized anti-CD40L monoclonal antibody or mAb),...
ASPEN trial finds roxadustat effective for treating anaemia in large dialysis...
New research has been published in Hemodialysis International which, say its authors, “enhances understanding” of how haemodialysis centres can utilise oral roxadustat. The anaemia...
ProKidney announces new vice president of clinical development
ProKidney, a late clinical-stage cellular therapeutics company focused on chronic kidney disease (CKD), has announced the appointment of Bruce Culleton as executive vice president...
New data shared on ferric citrate for dialysis patients
Akebia Therapeutics has announced topline results from IMPACT, a phase 4 collaborative study investigating the impact of Auryxia (ferric citrate) when used as the...
Posoleucel safe and effective for BK infection in kidney transplant recipients,...
AlloVir, a late-clinical stage allogeneic T cell immunotherapy company, has announced the presentation of final results from a Phase 2 study of posoleucel, an...
First enrolment in trial of secondary hyperparathyroidism drug for ESKD patients
Pathalys Pharma and Launch Therapeutics have announced that the first patient has been enrolled in the PATH (PTH Attenuation Trial in Hemodialysis) clinical programme,...
Anaemia drug Vafseo approved for treatment of dialysis patients
Akebia Therapeutics has announced that the European Commission (EC) has granted marketing authorisation for Vafseo (vadadustat), an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor...
MAGMA trial results suggest spironolactone effective for CKD
The main results of the Magnetic Resonance Imaging Evaluation of Mineralocorticoid Receptor Antagonism in Diabetic Atherosclerosis (MAGMA) trial, a National Heart, Lung, and Blood...
Artificial kidney for early detection of drug toxicity developed
The kidney plays a vital role in maintaining homeostasis within the body by eliminating toxic and superfluous substances in the bloodstream, including waste generated...
Pharmacological approaches to reducing arteriovenous fistula failure rates
Sanjay Misra (Rochester, USA) discusses the need for pharmacological approaches that can improve successful, long-term outcomes with arteriovenous fistulas (AVFs) and outlines a handful...